Pain meds stopped working?

Has anyone experienced a honeymoon effect with pain medication? As in it feels like it works and definitely helps with the pain for about a couple of days maybe even for two weeks but then slowly, but surely the pain starts coming back and feels as if you never started it?

This happened to me with pregablin (trialed for 1-2 months - stopped being effective 3 weeks in), now it’s happening with cymbalta, at 60mg. How is this even possible it’s only been 2 weeks?