Mustang lifespan

I recently had to replace my 2010 mustang v6 with a new transmission, and it got me thinking,

I have around 130k miles on it, and at this point want it to last longer than the 70k more it realistically will last, as i plan on putting some mods in the car.

If i replace the engine and suspension when they go, could i realistically get to like 280k - 320k miles without it being toooo much of a waste of money (with the logic of replacing the engine and suspension instead of buying a new car)