Icariin - erectile function improvement, promotion of testosterone production and modulation of endogenous stem cells to promote regeneration of damaged penile tissues

https://tau.amegroups.org/article/view/97001/html

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This narative review was certainly a fun read.

"Researches in recent years have demonstrated the therapeutic effects of ICA, ICAII (an ICA metabolite isolated from epimedium herb) and its synthetic derivative YS-10 on ED, including inhibition of PDE5 enzymatic activity, promotion of testosterone production, and modulation of endogenous stem cells to promote regeneration of damaged penile tissues"

but also..

" ICA has been used for efficacy and mechanism studies in a variety of diseases, but no human data is currently available. This is likely to be the most important direction for future research. High quality and large sample of clinical and evidence-based medicine studies are recommended while ensuring safety."