Specifically male neurotypical gamers that do a Let's Play, don't listen to any of the instructions or storyline, and don't play the game properly.

I say make neurotypical gamers because I personally have never seen this is female gamers, (im not saying female gamers like this don't exist, but it's definitely predominately men) and the neurotypical male gamers I watch actually pay attention to the instructions, and if they don't, they go back to the instructions to hear it again.

I can't explain why but it just pmo so badly cuz they'll be talking over the game, talking to their chat, while it's doing the introduction with the instructions and storyline set up, and then go "why isn't it telling me what to do I don't know what to do?"

And then for the rest of the game they continue not to listen to the given instructions, and do everything wrong, get mad because they keep failing/dying, and give up the game cuz they say it's a bad game.

No, you're just a bad gamer.

Bonus points of annoyance if it's a game based to younger audiences that are so much easier to complete because it will keep prompting you with instructions.

An example of this was when Piglet's Big Game became popular again. I played it growing up so naturally I know every location for cookies and how to beat everything by heart. And people who take time to understand are not the issue. But there was this one guy who did it and he didn't listen to any instructions given, refused to collect the cookies which are needed to progress (as it tells you like 3 times each level), and it just pmo so badly.