What I don’t understand about coronary calcification progression
As I understand it, the presence of soft plaques in the 4 main arteries is the substrate on which calcification occurs.
Namely, soft plaques are a precursor to calcification.
From many articles I’ve read online, it is said that once calcification begins, it continues as X % rate per year (I’ve read anywhere from 10 to 25% per year).
To me, this makes sense if soft plaque formation is continuing
However, what if you significantly slow down soft plaque formation through medication and lifestyle changes (i.e., LDL levels <50) ?
From there, I would only expect that calcification continue on the existing soft plaques that have developed before the lifestyle+pharmacological intervention.
But once those plaques are calcified, what more is there left to calcify?
Shouldn’t the expectation be: “If soft plaque formation is slowed down significantly, coronary artery calcification will continue to rise (especially with statin therapy) up until the remaining, untreated soft plaques, are calcified. After that, there will be no remaining soft plaques to calcify, thereby reducing the rate at which calcification occurs”
Open to your thoughts.