Themes of Regions
Do you think that the regions represent harmful coping mechanisms to despair? The game is centered around the cycle of failure and how victory can be achieved through self growth, so it would make sense that the enemies would be representing the many ways you can curb that self growth.
Sprawl: Ignorance leads to stagnation, not perfection.
Tangle: Sloth chokes the action of ambition before it begins.
Foetor: Gluttony and addiction rewards the perverse action.
Shroud: Idolatry relinquishes all hope and faith from the self.
Sluice: Pig.
The Mountain: Oblivion welcomed is a cruelty beyond death.
edit—tried to fix the list’s formatting so it doesn’t mash together into an unreadable block