What are some examples of actors playing against type that stood out to you?

Recently I saw Ving Rhames and Alfre Woodard in Holiday Heart and it's basically both of them playing against type

Rhames, who usually plays tough guys, plays an effeminate, flamboyant drag queen. Alfre Woodard, who usually plays responsible, mature, and even sometimes maternal authority figures, plays a drug addicted, flaky Mom always abandoning her child and dating the worst men

I was honestly impressed to see them play characters opposite of who they usually play and pull it off well!

Also even the director is playing against type because it's directed by Robert Townsend, a man known more for comedies. Like if you watched it you'd never assume it's directed by the director of Meteor Man and BAPS!

For a TV Show example though definitely Bill Hader and Stephen Root in Barry. However Root arguably also played against type in Get Out playing a much darker character than the usual bumbling idiots he often plays in comedies.