Do you keep adding mods during your play through or do you settle on one and stick to it until the end?

I'm having a hard time narrowing down what mods I want and I keep either wanting to downsize my list or add more because as I am playing I go "oh hey, I wonder if there's a mod for this" and 90% of the time, there is! I have not played the damn game even to level 50 in probably 2 years. I just start over constantly and it's become really frustrating as I have bad OCD tendencies.

This might not be the right place for this but how did everyone decide on a list and not feel the need to tweak them. Or on the other hand anybody play vanilla ( or mostly ) and still happy with the game?