Why use an amp sim pedal?

I’m in the process of refining my DI rig. I’m not speaking in favor of any one method but I am curious as to why someone would use something like a Strymon Iridium, Walrus ACS1 or UAD Dream into an audio interface instead of going straight in and using software like Neural DSP or ToneX. I have yet to use an amp pedal. Is it mostly just about having a physical “amp” to manipulate? Is there a sound quality difference?