Question about taking a new job, would you take the jump?

I've worked at an MSP for the past 4 years making about 75k a year at a HCOL area. I've gotten a few raises and promotions since I've started working here but I dont really see any further advancement for me personally. I am pretty comfortable here as I know all of our clients infrastructure and users.

Recently I received an offer to be internal IT for a financial company with a 45% pay increase as a systems administrator. This will put me into 6 figure territory. I can work from home basically the same amount as current job. I will be just myself and the IT manager dealing with a small company of about 50 users. One downside would be there is an upcoming busy season which will last a few months that will have longer than usual work hours. Another downside is they have the "Unlimited PTO" thing going for them.

I am also a bit nervous in general since I've found stable income with my current role for the past 4 years. Maybe this new job doesnt work out. A bunch of what ifs.