Has anyone found a medication that made a difference after several years of searching?

I’ve struggled with depression for 10 years at this point. I’ve tried a bunch of medications but nothing seems to make a significant difference. (My doctor hasn’t been particularly helpful either). I’m trying to see a psychiatrist, but of course there’s a wait for that. Right now, I’m not on any medication. Even though, the meds didn’t do much, knowing they were there provided some comfort. I’m scared that I won’t make it through. I’m tired. I’m afraid the relief I’m seeking doesn’t exist.