Stay in Shenzhen and day trips to Guangzhou or the other way around?

After spending a few days in Hong Kong I’ll be visiting Shenzhen and Guangzhou for 6 days and am wondering whether I should make Shenzhen or Guangzhou my base for day tripping to other locations?

I’d like to hit all the typical tourist sights in the Guangdong area, and see stuff like skylines, temples, street food, nightlife, and museums.

Or would it be better to stay in Shenzhen and Guangzhou each for three nights?